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References/Additional Resources

  1. Haywood VB, Heymann HO. Nightguard vital bleaching. Quintessence Int. 1989 Mar;20(3):173-6.

  2. Jahangiri L, Reinhardt SB, Mehra RV, Matheson PB. Relationship between tooth shade value and skin color: an observational study. J Prosthet Dent. 2002 Feb;87(2):149-52.

  3. Al-Nsour HF, Al-Zoubi TT, Al-Rimawi AS. Relationship between tooth value and skin color in patients visiting Royal Medical Services clinics of Jordan. Electron Physician. 2018 Mar 25;10(3):6448-6453.

  4. Vadavadagi SV, Kumari KV, Choudhury GK, Vilekar AM, Das SS, Jena D, Kataraki B, B L B. Prevalence of Tooth Shade and its Correlation with Skin Colour - A Cross-sectional Study. J Clin Diagn Res. 2016 Feb;10(2):ZC72-4.

  5. Joiner A. Tooth colour: a review of the literature. J Dent. 2004;32 Suppl 1:3-12.

  6. Kugel G, Gerlach RW, Aboushala A, Ferreira S, Magnuson B. Long-term use of 6.5% hydrogen peroxide bleaching strips on tetracycline stain: a clinical study. Compend Contin Educ Dent. 2011 Oct;32(8):50-6.

  7. Kugel G, Aboushala A, Zhou X, Gerlach RW. Daily use of whitening strips on tetracycline-stained teeth: comparative results after 2 months. Compend Contin Educ Dent. 2002 Jan;23(1A):29-34.

  8. Leonard RH Jr. Nightguard vital bleaching: dark stains and long-term results. Compend Contin Educ Dent Suppl. 2000;(28):S18-27.

  9. Addy M, Moran J. Extrinsic tooth discoloration by metals and chlorhexidine. II. Clinical staining produced by chlorhexidine, iron and tea. Br Dent J. 1985 Nov 23;159(10):331-4.

  10. Addy M, Moran J, Griffiths AA, Wills-Wood NJ. Extrinsic tooth discoloration by metals and chlorhexidine. I. Surface protein denaturation or dietary precipitation? Br Dent J. 1985 Nov 9;159(9):281-5.

  11. Vogel RI. Intrinsic and extrinsic discoloration of the dentition (a literature review). J Oral Med. 1975 Oct-Dec;30(4):99-104.

  12. Karaman T, Altintas E, Eser B, Talo Yildirim T, Oztekin F, Bozoglan A. Spectrophotometric Evaluation of Anterior Maxillary Tooth Color Distribution According to Age and Gender. J Prosthodont. 2019 Jan;28(1):e96-e102.

  13. Gómez-Polo C, Montero J, Gómez-Polo M, de Parga JA, Celemin-Viñuela A. Natural Tooth Color Estimation Based on Age and Gender. J Prosthodont. 2017 Feb;26(2):107-114.

  14. Hassel AJ, Johanning M, Grill S, Schröder J, Wahl HW, Corcodel N, Klotz AL, Rammelsberg P, Zenthöfer A. Changes of tooth color in middle and old age: A longitudinal study over a decade. J Esthet Restor Dent. 2017 Nov 12;29(6):459-463.

  15. Falcone ME, Kelly JR, Rungruanganut P. In Vivo Color Relationships Between the Maxillary Central Incisors and Canines as a Function of Age. Int J Prosthodont. 2016 Sep-Oct;29(5):496-502.

  16. Vaidya S, Ahuja N, Bajaj P, Kapoor C, Sabarwal R, Rajpal K. Objective measurement of shade color in age estimation. J Forensic Dent Sci. 2015 Sep-Dec;7(3):171-4.

  17. Epple M, Meyer F, Enax J. A Critical Review of Modern Concepts for Teeth Whitening. Dent J (Basel). 2019 Aug 1;7(3):79.

  18. Li Y. Stain removal and whitening by baking soda dentifrice: A review of literature. J Am Dent Assoc. 2017 Nov;148(11S):S20-S26.

  19. White DJ. Development of an improved whitening dentifrice based upon "stain-specific soft silica" technology. J Clin Dent. 2001;12(2):25-9.

  20. Isaacs RL, Bartizek RD, Owens TS, Walters PA, Gerlach RW. Maintenance of tooth color after prophylaxis: comparison of three dentifrices. J Clin Dent. 2001;12(2):51-5.

  21. Joiner A. Whitening toothpastes: a review of the literature. J Dent. 2010;38 Suppl 2:e17-24.

  22. St John S, White DJ. History of the Development of Abrasivity Limits for Dentifrices. J Clin Dent. 2015;26(2):50-4.

  23. Busscher H, White D, van der Mei H, Baig A, Kozak K. Hexametaphosphate effects on tooth surface conditioning film chemistry--in vitro and in vivo studies. J Clin Dent. 2002;13(1):38-43.

  24. Baig A, He T, Buisson J, Sagel L, Suszcynsky-Meister E, White DJ. Extrinsic whitening effects of sodium hexametaphosphate--a review including a dentifrice with stabilized stannous fluoride. Compend Contin Educ Dent. 2005 Sep;26(9 Suppl 1):47-53.

  25. Bollmer BW, Sturzenberger OP, Vick V, Grossman E. Reduction of calculus and Peridex stain with Tartar-Control Crest. J Clin Dent. 1995;6(4):185-7.

  26. Gerlach R, Ramsey L, Baker R, White D. Extrinsic stain prevention with a combination dentifrice containing calcium phosphate surface active builders compared to two marketed controls. J Clin Dent. 2002;13(1):15-8.

  27. Sagel PA, Odioso LL, McMillan DA, Gerlach RW. Vital tooth whitening with a novel hydrogen peroxide strip system: design, kinetics, and clinical response. Compend Contin Educ Dent Suppl. 2000;(29):S10-5.

  28. Klukowska M, Götz H, White DJ, Zoladz J, Schwarz BO, Duschner H. Depth profile analysis of non-specific fluorescence and color of tooth tissues after peroxide bleaching. Am J Dent. 2013 Feb;26(1):3-9.

  29. Junyuan Qin, Li Zeng, Wei Min, Licheng Tan, Ruizhi Lv, Yiwang Chen,A bio-safety tooth-whitening composite gels with novel phthalimide peroxy caproic acid, Composites Communications, 2019; 13: 107-111.

  30. Kugel G, Ferreira S, Sharma S, Barker M, Gerlach R. Clinical trial assessing light enhancement of in-office tooth whitening. Esthet Restor Dent. 2009;21 (5); 336-347

  31. Gerlach RW. Shifting paradigms in whitening: introduction of a novel system for vital tooth bleaching. Compend Contin Educ Dent Suppl. 2000;(29):S4-9.

  32. Walsh LJ. Safety issues relating to the use of hydrogen peroxide in dentistry. Aust Dent J. 2000 Dec;45(4):257-69.

  33. Liochev SI. Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med. 2013 Jul;60:1-4.

  34. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006 Mar 10;160(1):1-40.

  35. Davies MJ. Protein oxidation and peroxidation. Biochem J. 2016 Apr 1;473(7):805-25.

  36. Staerck C, Gastebois A, Vandeputte P, Calenda A, Larcher G, Gillmann L, Papon N, Bouchara JP, Fleury MJJ. Microbial antioxidant defense enzymes. Microb Pathog. 2017 Sep;110:56-65.

  37. Zhang YJ, Gan RY, Li S, Zhou Y, Li AN, Xu DP, Li HB. Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases. Molecules. 2015 Nov 27;20(12):21138-56.

  38. Glorieux C, Calderon PB. Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach. Biol Chem. 2017 Sep 26;398(10):1095-1108.

  39. Kielbassa AM, Maier M, Gieren AK, Eliav E. Tooth sensitivity during and after vital tooth bleaching: A systematic review on an unsolved problem. Quintessence Int. 2015 Nov-Dec;46(10):881-97.

  40. Maran BM, Vochikovski L, de Andrade Hortkoff DR, Stanislawczuk R, Loguercio AD, Reis A. Tooth sensitivity with a desensitizing-containing at-home bleaching gel-a randomized triple-blind clinical trial. J Dent. 2018 May;72:64-70.

  41. de Paula B, Alencar C, Ortiz M, Couto R, Araújo J, Silva C. Effect of photobiomodulation with low-level laser therapy combined with potassium nitrate on controlling post-bleaching tooth sensitivity: clinical, randomized, controlled, double-blind, and split-mouth study. Clin Oral Investig. 2019 Jun;23(6):2723-2732.

  42. Wang Y, Gao J, Jiang T, Liang S, Zhou Y, Matis BA. Evaluation of the efficacy of potassium nitrate and sodium fluoride as desensitizing agents during tooth bleaching treatment—A systematic review and meta-analysis. J Dent. 2015 Aug;43(8):913-23

  43. Benetti F, Gomes-Filho JE, Ferreira LL, Sivieri-Araújo G, Ervolino E, Briso ALF, Cintra LTA. Concentration-dependent effect of bleaching agents on the immunolabelling of interleukin-6, interleukin-17 and CD5-positive cells in the dental pulp. Int Endod J. 2018 Jul;51(7):789-799.

  44. Benetti F, Gomes-Filho JE, Ferreira LL, Ervolino E, Briso ALF, Sivieri-Araújo G, Dezan-Júnior E, Cintra LTA. Hydrogen peroxide induces cell proliferation and apoptosis in pulp of rats after dental bleaching in vivo: Effects of the dental bleaching in pulp. Arch Oral Biol. 2017 Sep;81:103-109.

  45. Soares DG, Basso FG, Hebling J, de Souza Costa CA. Concentrations of and application protocols for hydrogen peroxide bleaching gels: effects on pulp cell viability and whitening efficacy. J Dent. 2014 Feb;42(2):185-98.

  46. Silva-Costa RSGD, Ribeiro AEL, Assunção IV, Araújo Júnior RF, Araújo AA, Guerra GCB, Borges BCD. In-office tooth bleaching with 38% hydrogen peroxide promotes moderate/severe pulp inflammation and production of ll-1β, TNF-β, GPX, FGF-2 and osteocalcin in rats. J Appl Oral Sci. 2018 Jun 11;26:e20170367.

  47. Karaarslan ES, Özmen ZC, Aytac F, Bicakci AA, Buldur M, Aydogan L, Hologlu F, Özkocak B. Evaluation of biochemical changes in dental tissues after different office bleaching methods. Hum Exp Toxicol. 2019 Apr;38(4):389-397.

  48. Sato C, Rodrigues FA, Garcia DM, Vidal CM, Pashley DH, Tjäderhane L, Carrilho MR, Nascimento FD, Tersariol IL. Tooth bleaching increases dentinal protease activity. J Dent Res. 2013 Feb;92(2):187-92.

  49. Vaz MM, Lopes LG, Cardoso PC, Souza JB, Batista AC, Costa NL, Torres ÉM, Estrela C. Inflammatory response of human dental pulp to at-home and in-office tooth bleaching. J Appl Oral Sci. 2016 Sep-Oct;24(5):509-517.

  50. Benetti F, Briso ALF, Carminatti M, de Araújo Lopes JM, Barbosa JG, Ervolino E, Gomes-Filho JE, Cintra LTA. The presence of osteocalcin, osteopontin and reactive oxygen species-positive cells in pulp tissue after dental bleaching. Int Endod J. 2019 May;52(5):665-675.

  51. Bowles WH, Burns H Jr. Catalase/peroxidase activity in dental pulp. J Endod. 1992 Nov;18(11):527-34.

  52. Epple M, Meyer F, Enax J. A Critical Review of Modern Concepts for Teeth Whitening. Dent J (Basel). 2019 Aug 1;7(3):79.

  53. Bersezio C, Martín J, Angel P, Bottner J, Godoy I, Avalos F, Fernández E. Teeth whitening with 6% hydrogen peroxide and its impact on quality of life: 2 years of follow-up. Odontology. 2019 Jan;107(1):118-125. doi: 10.1007/s10266-018-0372-3.

  54. Pinto MM, Gonçalves ML, Mota AC, Deana AM, Olivan SR, Bortoletto C, Godoy CH, Vergilio KL, Altavista OM, Motta LJ, Bussadori SK. Controlled clinical trial addressing teeth whitening with hydrogen peroxide in adolescents: a 12-month follow-up. Clinics (Sao Paulo). 2017 Mar;72(3):161-170.

  55. Estay J, Angel P, Bersezio C, Tonetto M, Jorquera G, Peña M, Fernández E. The change of teeth color, whiteness variations and its psychosocial and self-perception effects when using low vs. high concentration bleaching gels: a one-year follow-up. BMC Oral Health. 2020 Sep 11;20(1):255.

  56. Auschill TM, Schneider-Del Savio T, Hellwig E, Arweiler NB. Randomized clinical trial of the efficacy, tolerability, and long-term color stability of two bleaching techniques: 18-month follow-up. Quintessence Int. 2012 Sep;43(8):683-94.

  57. Moghadam FV, Majidinia S, Chasteen J, Ghavamnasiri M. The degree of color change, rebound effect and sensitivity of bleached teeth associated with at-home and power bleaching techniques: A randomized clinical trial. Eur J Dent. 2013 Oct;7(4):405-411.

  58. Kugel G, Gerlach R, Aboushala A, Ferreira S, Magnuson B. Long-Term Use of 6.5% Hydrogen Peroxide Bleaching Strips on Tetracycline Stain: A Clinical Study. Compendium of Continuing Education in Dentistry. 2011 Oct; 32 (8)

  59. Llena C, Villanueva A, Mejias E, Forner L. Bleaching efficacy of at home 16% carbamide peroxide. A long-term clinical follow-up study. J Esthet Restor Dent. 2020 Jan;32(1):12-18.

  60. Amato A, Caggiano M, Pantaleo G, Amato M. In-office and walking bleach dental treatments on endodontically-treated teeth: 25 years follow-up. Minerva Stomatol. 2018 Dec;67(6):225-230.

  61. Markowitz K, Pretty painful: Why does tooth bleaching hurt?, Medical Hypotheses, Volume 74, Issue 5, 2010, Pages 835-840, ISSN 0306-9877.

  62. Tredwin CJ, Naik S, Lewis NJ, Scully C. Hydrogen peroxide tooth-whitening (bleaching) products: review of adverse effects and safety issues. Br Dent J. 2006 Apr 8;200(7):371-6.

  63. Li Y, Greenwall L. Safety issues of tooth whitening using peroxide-based materials. Br Dent J. 2013 Jul;215(1):29-34.

  64. Demarco FF, Meireles SS, Masotti AS. Over-the-counter whitening agents: a concise review. Braz Oral Res. 2009;23 Suppl 1:64-70.

  65. Walsh LJ. Safety issues relating to the use of hydrogen peroxide in dentistry. Aust Dent J. 2000 Dec;45(4):257-69.

  66. Sulieman MA. An overview of tooth-bleaching techniques: chemistry, safety and efficacy. Periodontol 2000. 2008;48:148-69.

  67. Attin T, Hannig C, Wiegand A, Attin R. Effect of bleaching on restorative materials and restorations--a systematic review. Dent Mater. 2004 Nov;20(9):852-61.

  68. Irawan BA, Irawan SN, Masudi SM, Sukminingrum N, Alam MK. 3D Surface Profile and Color Stability of Tooth Colored Filling Materials after Bleaching. Biomed Res Int. 2015:327-289.

  69. Corcodel N, Hassel AJ, Sen S, Saure D, Rammelsberg P, Lux CJ, Zingler S. Effect of enamel sealants on tooth bleaching and on the color stability of the result. Odontology. 2017 Apr;105(2):155-161.

  70. Rodrigues CS, Nora BD, Mallmann A, May LG, Jacques LB. Repolishing Resin Composites After Bleaching Treatments: Effects on Color Stability and Smoothness. Oper Dent. 2019 Jan/Feb;44(1):54-64.

  71. Jain V, Das TK, Pruthi G, Shah N, Rajendiran S. Comparative evaluation of effects of bleaching on color stability and marginal adaptation of discolored direct and indirect composite laminate veneers under in vivo conditions. J Indian Prosthodont Soc. 2015 Jan-Mar;15(1):46-52.

  72. Attin T, Hannig C, Wiegand A, Attin R. Effect of bleaching on restorative materials and restorations--a systematic review. Dent Mater. 2004 Nov;20(9):852-61.

  73. Swift EJ Jr, Perdigão J. Effects of bleaching on teeth and restorations. Compend Contin Educ Dent. 1998 Aug;19(8):815-20.

  74. Swift EJ Jr. Restorative considerations with vital tooth bleaching. J Am Dent Assoc. 1997 Apr;128 Suppl:60S-64S.

  75. Rodríguez-Martínez J, Valiente M, Sánchez-Martín MJ. Tooth whitening: From the established treatments to novel approaches to prevent side effects. J Esthet Restor Dent. 2019 Sep;31(5):431-440.

  76. Kielbassa AM, Maier M, Gieren AK, Eliav E. Tooth sensitivity during and after vital tooth bleaching: A systematic review on an unsolved problem. Quintessence Int. 2015 Nov-Dec;46(10):881-97.

  77. Wang Y, Gao J, Jiang T, Liang S, Zhou Y, Matis BA. Evaluation of the efficacy of potassium nitrate and sodium fluoride as desensitizing agents during tooth bleaching treatment—A systematic review and meta-analysis. J Dent. 2015 Aug;43(8):913-23.

  78. Rezende M, Coppla FM, Chemin K, Chibinski AC, Loguercio AD, Reis A. Tooth Sensitivity After Dental Bleaching With a Desensitizer-containing and a Desensitizer-free Bleaching Gel: A Systematic Review and Meta-analysis. Oper Dent. 2019 Mar/Apr;44(2):E58-E74.

  79. Estay J, Vernal R, Haidar ZS, Angel P, Oliveira OB Jr, Fernández E. Quality of life and stability of tooth color change at three months after dental bleaching. Qual Life Res. 2018 Dec;27(12):3199-3207. doi: 10.1007/s11136-018-1972-7.

  80. Karadas M. Efficacy of whitening oral rinses and dentifrices on color stability of bleached teeth. Acta Biomater Odontol Scand. 2015 Apr 27;1(1):29-34.

  81. Joiner A. Whitening toothpastes: a review of the literature. J Dent. 2010;38 Suppl 2:e17-24.

  82. Bartizek RD, Walters P, Biesbrock AR. The prevention of induced stain using two levels of sodium hexametaphosphate in chewing gum. J Clin Dent. 2003;14(4):77-81.

  83. Gerlach R, Ramsey L, Baker R, White D. Extrinsic stain prevention with a combination dentifrice containing calcium phosphate surface active builders compared to two marketed controls. J Clin Dent. 2002;13(1):15-8.

  84. Li Y, He T, Sun L, Zhang Y, Li X, Wang Y, Zhao S, Tang R. Extrinsic stain removal efficacy of a dual-phase dentifrice. Am J Dent. 2007 Aug;20(4):227-30.

  85. Ontiveros JC, Paravina RD. Color change of vital teeth exposed to bleaching performed with and without supplementary light. J Dent. 2009;37(11):840-847.

  86. Bernardon JK, Sartori N, Ballarin A, Perdigao J, Lopes GC, Baratieri LN. Clinical performance of vital bleaching techniques. Oper Dent. 2010;35(1):3-10.

  87. Marson FC, Sensi LG, Vieira LC, Araujo E. Clinical evaluation of in-office dental bleaching treatments with and without the use of light-activation sources. Oper Dent. 2008;33(1):15-22.

  88. Sulieman M, Addy M, Macdonald E, Rees JS. A safety study in vitro for the effects of an in-office bleaching system on the integrity of enamel and dentine. J Dent. 2004;32(7):581- 590.

  89. Kiomars N, Azarpour P, Mirzaei M, Hashemi Kamangar SS, Kharazifard MJ, Chiniforush N. Evaluation of the Diode laser (810nm, 980 nm) on color change of teeth after external bleaching. after external bleaching. Laser Ther. 2016;25(4):267-272.

  90. De Moor RJ, Verheyen J, Verheyen P, Diachuk A, Meire MA, De Coster PJ, De Bruyne M, Keulemans F. Laser teeth bleaching: evaluation of eventual side effects on enamel and the pulp and the efficiency in vitro and in vivo. ScientificWorldJournal. 2015;2015:835405.

  91. Maran BM, Burey A, de Paris Matos T, Loguercio AD, Reis A. In-office dental bleaching with light vs. without light: A systematic review and meta-analysis. J Dent. 2018 Mar;70:1-13.

  92. Maran BM, Ziegelmann PK, Burey A, de Paris Matos T, Loguercio AD, Reis A. Different light-activation systems associated with dental bleaching: a systematic review and a network meta-analysis. Clin Oral Investig. 2019 Apr;23(4):1499-1512.

  93. SoutoMaior JR, de Moraes S, Lemos C, Vasconcelos BDE, Montes M, Pellizzer EP. Effectiveness of Light Sources on In-Office Dental Bleaching: A Systematic Review and Meta-Analyses. Oper Dent. 2019 May/Jun;44(3):E105-E117.

  94. lshammery S. Evaluation of Light Activation on In-office Dental Bleaching: A Systematic Review. J Contemp Dent Pract. 2019 Nov 1;20(11):1355-1360.

  95. Kikly A, Jaâfoura S, Sahtout S. Vital laser-activated teeth bleaching and postoperative sensitivity: A systematic review. J Esthet Restor Dent. 2019 Sep;31(5):441-450.

  96. He LB, Shao MY, Tan K, Xu X, Li JY. The effects of light on bleaching and tooth sensitivity during in-office vital bleaching: a systematic review and meta-analysis. J Dent. 2012 Aug;40(8):644-53.

  97. Benetti F, Lemos CAA, de Oliveira Gallinari M, Terayama AM, Briso ALF, de Castilho Jacinto R, Sivieri-Araújo G, Cintra LTA. Influence of different types of light on the response of the pulp tissue in dental bleaching: a systematic review. Clin Oral Investig. 2018 May;22(4):1825-1837. doi: 10.1007/s00784-017-2278-9.

  98. De Moor RJ, Verheyen J, Verheyen P, Diachuk A, Meire MA, De Coster PJ, De Bruyne M, Keulemans F. Laser teeth bleaching: evaluation of eventual side effects on enamel and the pulp and the efficiency in vitro and in vivo. ScientificWorldJournal. 2015;2015:835405.

  99. Pleffken PR, Borges AB, Gonçalves SE, Rocha Gomes Torres C. The effectiveness of low-intensity red laser for activating a bleaching gel and its effect in temperature of the bleaching gel and the dental pulp. J Esthet Restor Dent. 2012 Apr;24(2):126-32.

  100. Luque-Martinez I, Reis A, Schroeder M, Muñoz MA, Loguercio AD, Masterson D, Maia LC. Comparison of efficacy of tray-delivered carbamide and hydrogen peroxide for at-home bleaching: a systematic review and meta-analysis. Clin Oral Investig. 2016 Sep;20(7):1419-33.

  101. Alonso de la Peña V, López Ratón M. Randomized clinical trial on the efficacy and safety of four professional at-home tooth whitening gels. Oper Dent. 2014 Mar-Apr;39(2):136-43.

  102. Türkün M, Celik EU, Aladağ A, Gökay N. One-year clinical evaluation of the efficacy of a new daytime at-home bleaching technique. J Esthet Restor Dent. 2010 Apr;22(2):139-46.

  103. Burrows S. A review of the efficacy of tooth bleaching. Dent Update. 2009 Nov;36(9):537-8, 541-4, 547-8 passim. doi: 10.12968/denu.2009.36.9.537.

  104. Delgado E, Hernández-Cott PL, Stewart B, Collins M, De Vizio W. Tooth-whitening efficacy of custom tray-delivered 9% hydrogen peroxide and 20% carbamide peroxide during daytime use: a 14-day clinical trial. P R Health Sci J. 2007 Dec;26(4):367-72.

  105. Hasturk H, Nunn M, Warbington M, Van Dyke TE. Efficacy of a fluoridated hydrogen peroxide-based mouthrinse for the treatment of gingivitis: a randomized clinical trial. J Periodontol. 2004 Jan;75(1):57-65. doi: 10.1902/jop.2004.75.1.57.

  106. Gerlach RW, Barker ML, Tucker HL. Clinical response of three whitening products having different peroxide delivery: comparison of tray, paint-on gel, and dentifrice. J Clin Dent. 2004;15(4):112-7.

  107. Oliveira GM, Miguez PA, Oliveira GB, Swift EJ Jr, Farrell S, Anastasia MK, Conde E, Walter R. Safety and efficacy of a high-adhesion whitening strip under extended wear regimen. J Dent. 2013 Aug;41 Suppl 3:e46-52.

  108. Yudhira R, Peumans M, Barker ML, Gerlach RW. Clinical trial of tooth whitening with 6% hydrogen peroxide whitening strips and two whitening dentifrices. Am J Dent. 2007 Sep;20 Spec No A:32A-36A. Erratum in: Am J Dent. 2009 Apr;22(2):114.

  109. Donly KJ, Segura A, Sasa I, Perez E, Anastasia MK, Farrell S. A controlled clinical trial to evaluate the safety and whitening efficacy of a 9.5% hydrogen peroxide high-adhesion whitening strip in a teen population. Am J Dent. 2010 Oct;23(5):292-6.

  110. Botelho MG, Chan AWK, Newsome PRH, McGrath CP, Lam WYH. A randomized controlled trial of home bleaching of tetracycline-stained teeth. J Dent. 2017 Dec;67:29-35.

  111. Karpinia K, Magnusson I, Barker ML, Gerlach RW. Clinical comparison of two self-directed bleaching systems. J Prosthodont. 2003 Dec;12(4):242-8.

  112. Gerlach RW, Barker ML. Clinical response of three direct-to-consumer whitening products: strips, paint-on gel, and dentifrice. Compend Contin Educ Dent. 2003 Jun;24(6):458, 461-464.

  113. Gerlach RW, Barker ML, Sagel PA. Comparative efficacy and tolerability of two direct-to-consumer tooth whitening systems. Am J Dent. 2001 Oct;14(5):267-72.

  114. Kugel G, Gerlach RW, Aboushala A, Ferreira S, Magnuson B. Long-term use of 6.5% hydrogen peroxide bleaching strips on tetracycline stain: a clinical study. Compend Contin Educ Dent. 2011 Oct;32(8):50-6.

  115. Kugel G, Aboushala A, Zhou X, Gerlach RW. Daily use of whitening strips on tetracycline-stained teeth: comparative results after 2 months. Compend Contin Educ Dent. 2002 Jan;23(1A):29-34.

  116. Barlow A, Gerlach RW, Date RF, Brennan K, Struzycka I, Kwiatkowska A, Wierzbicka M. Clinical response of two brush-applied peroxide whitening systems. J Clin Dent. 2003;14(3):59-63.

  117. Gerlach RW, Barker ML. Randomized clinical trial comparing overnight use of two self-directed peroxide tooth whiteners. Am J Dent. 2003 Nov;16 Spec No:17B-21B.

  118. Bizhang M, Müller M, Phark JH, Barker ML, Gerlach RW. Clinical trial of long-term color stability of hydrogen peroxide strips and sodium percarbonate film. Am J Dent. 2007 Sep;20 Spec No A:23A-27A. Erratum in: Am J Dent. 2009 Apr;22(2):114.

  119. Gerlach RW, Barker ML. Clinical response of three direct-to-consumer whitening products: strips, paint-on gel, and dentifrice. Compend Contin Educ Dent. 2003 Jun;24(6):458, 461-4, 466 passim.

  120. Gerlach RW, Barker ML, Tucker HL. Clinical response of three whitening products having different peroxide delivery: comparison of tray, paint-on gel, and dentifrice. J Clin Dent. 2004;15(4):112-7.

  121. García-Godoy F, Villalta P, Bartizek RD, Barker ML, Biesbrock AR. Tooth whitening effects of an experimental power whitening toothbrush relative to an 8.7% hydrogen peroxide paint-on gel control. Am J Dent. 2004 Jan;17 Spec No:25A-30A.

  122. Gerlach RW, Barker ML, Tucker HL. Clinical response of three whitening products having different peroxide delivery: comparison of tray, paint-on gel, and dentifrice. J Clin Dent. 2004;15(4):112-7.

  123. Collins LZ, Maggio B, Liebman J, Blanck M, Lefort S, Waterfield P, Littlewood D, Naeeni M, Schäfer F. Clinical evaluation of a novel whitening gel, containing 6% hydrogen peroxide and a standard fluoride toothpaste. J Dent. 2004;32 Suppl 1:13-7.

  124. da Mata AD, Marques DN. A novel technique for in-office bleaching with a 6% hydrogen peroxide paint-on varnish. Eur J Esthet Dent. 2006 Apr;1(1):70-7.

  125. Nathoo S, Stewart B, Zhang YP, Chaknis P, Rustogi KN, DeVizio W, Petrone M, Volpe AR. Efficacy of a novel, nontray, paint-on 18% carbamide peroxide whitening gel. Compend Contin Educ Dent. 2002 Nov;23(11 Suppl 1):26-31.

  126. a Silva Marques DN, Silveira JM, Marques JR, Amaral JA, Guilherme NM, da Mata AD. Kinetic release of hydrogen peroxide from different whitening products. Eur J Esthet Dent. 2012 Autumn;7(3):344-52.

  127. Barlow A, Gerlach RW, Date RF, Brennan K, Struzycka I, Kwiatkowska A, Wierzbicka M. Clinical response of two brush-applied peroxide whitening systems. J Clin Dent. 2003;14(3):59-63.

  128. Kim HJ, Jang JH, Choi D, Kim J, Shim JH, Kim DS. Bleaching toothpaste with two different concentrations of hydrogen peroxide: A randomized double-blinded clinical trial. J Dent. 2020 Oct 26;103:103508.

  129. Demarco FF, Meireles SS, Masotti AS. Over-the-counter whitening agents: a concise review. Braz Oral Res. 2009;23 Suppl 1:64-70.

  130. Sagel PA, Gerlach RW. Clinical evidence on a unique two-step stannous fluoride dentifrice and whitening gel sequence. Am J Dent. 2018 Jul;31(Sp Is A):4A-6A.

  131. Fischman SL, Truelove RB, Hart R, Cancro LP. The laboratory and clinical safety evaluation of a dentifrice containing hydrogen peroxide and baking soda. J Clin Dent. 1992;3(4):104-10.

  132. Devila A, Lasta R, Zanella L, Agnol MD, Rodrigues-Junior SA. Efficacy and Adverse Effects of Whitening Dentifrices Compared With Other Products: A Systematic Review and Meta-analysis. Oper Dent. 2020 Mar/Apr;45(2):E77-E90.

  133. Naidu AS, Bennani V, Brunton JMAP, Brunton P. Over-the-Counter Tooth Whitening Agents: A Review of Literature. Braz Dent J. 2020 Jun;31(3):221-235.

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