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A-Z Fundamentals of Dentifrice: Oral Health Benefits in a Tube

Course Number: 670

References / Additional Resources

  1. Griffiths BM. Dentifrices--an item of historical interest. N Z Dent J. 1966 Oct;62(290):296-301

  2. Miller WD. The Micro-Organisms of the Human Mouth. Basel, Switzerland. S. Karger. 1973. doi:10.1002/jobm.19740140117. Accessed July 8, 2023.

  3. US Federal Food, Drug, & Cosmetic Act (FFDCA). 2018 Mar 29. Accessed June 17, 2023.

  4. Tenuta LM, Cury JA. Fluoride: its role in dentistry. Braz Oral Res. 2010;24 Suppl 1:9-17. doi:10.1590/s1806-83242010000500003.

  5. US FDA. Monograph System. Data Standards Manual (monographs). 2018 Feb 27. Accessed June 17, 2023.

  6. US Food & Drug Administration (FDA). Accessed June 17, 2023.

  7. American Dental Association (ADA). Seal of Acceptance Program. Accessed June 17, 2023.

  8. American Dental Association (ADA). Requirements for Product Acceptance. Accessed June 17, 2023.

  9. ADA Seal Brochure 2022

  10. Newbrun E. Water fluoridation and dietary fluoride - Fluorides and Dental Caries, 2nd ed. Ernest Newbrun (Ed). Springfield, IL. CC Thomas. 1975. 31-45.

  11. Dean HT, McKay FS, Elvone E. Mottled Enamel Survey of Bauxite, ARK., 10 Years After a Change in the Common Water Supply. Public Health Reports. 1896-1970;53(39):1736-1748. doi:10.2307/4582669.

  12. https://adanews.ada.org/ada-news/2021/august/community-water-fluoridation-prevents-caries/ Accessed Sept 2023

  13. Ten Great Public Health Achievements - United States, 1900-1999, CDC Morbidity and Mortality Weekly Report 1999 Apr 02;48(12):241-243. Accessed June 17, 2023.

  14. Bratthall D, Hänsel-Petersson G, Sundberg H. Reasons for the caries decline: what do the experts believe?. Eur J Oral Sci. 1996;104(4 ( Pt 2)):416-432. doi:10.1111/j.1600-0722.1996.tb00104.x.

  15. Tenuta LM, Zamataro CB, Del Bel Cury AA, Tabchoury CP, Cury JA. Mechanism of fluoride dentifrice effect on enamel demineralization. Caries Res. 2009;43(4):278-285. doi:10.1159/000217860.

  16. Cury JA, do Amaral RC, Tenuta LM, Del Bel Cury AA, Tabchoury CP. Low-fluoride toothpaste and deciduous enamel demineralization under biofilm accumulation and sucrose exposure. Eur J Oral Sci. 2010;118(4):370-375. doi:10.1111/j.1600-0722.2010.00745.x.

  17. Muhler JC, Radike AW, Nebergall WH, Day HG. The effect of a stannous fluoride-containing dentifrice on caries reduction in children. J Dent Res. 1954;33(5):606-612. doi:10.1177/00220345540330050401.

  18. Muhler JC, Radike AW. Effect of a dentifrice containing stannous fluoride on dental caries in adults. II. Results at the end of two years of unsupervised use. J Am Dent Assoc. 1957;55(2):196-198. doi:10.14219/jada.archive.1957.0157.

  19. American Dental Association, Council on Dental Therapeutics: Evaluation of Crest toothpaste. JADA. 1960 Aug;61(2):272-275.

  20. Chace R, American Dental Association. Reclassification of Crest toothpaste; Council on Dental Therapeutics. J Am Dent Assoc. 1964;69:195-196.

  21. Chronology of important chemical and related events since 1876. Chemical and Engineering News April 6th, 1976: 91-92.

  22. Featherstone JD. The caries balance: the basis for caries management by risk assessment. Oral Health Prev Dent. 2004;2 Suppl 1:259-264.

  23. Fejerskov O. Concepts of dental caries and their consequences for understanding the disease. Community Dent Oral Epidemiol. 1997;25(1):5-12. doi:10.1111/j.1600-0528.1997.tb00894.x.

  24. Silverstone LM. Laboratory studies on the demineralization and remineralization of human enamel in relation to caries mechanisms. Aust Dent J. 1980;25(3):163-168. doi:10.1111/j.1834-7819.1980.tb03707.x.

  25. Cury JA, Tenuta LM. Enamel remineralization: controlling the caries disease or treating early caries lesions?. Braz Oral Res. 2009;23 Suppl 1:23-30. doi:10.1590/s1806-83242009000500005.

  26. Posner AS. The mineral of bone. Clin Orthop Relat Res. 1985;(200):87-99.

  27. Dijkman A, Huizinga E, Ruben J, Arends J. Remineralization of human enamel in situ after 3 months: the effect of not brushing versus the effect of an F dentifrice and an F-free dentifrice. Caries Res. 1990;24(4):263-266. doi:10.1159/000261280.

  28. Clarkson JE, Ellwood RP, Chandler RE. A comprehensive summary of fluoride dentifrice caries clinical trials. Am J Dent. 1993;6 Spec No:S59-S106.

  29. White DJ. A "return" to stannous fluoride dentifrices. J Clin Dent. 1995;6 Spec No:29-36.

  30. Baig A, He T. A novel dentifrice technology for advanced oral health protection: A review of technical and clinical data. Compend Contin Educ Dent. 2005;26(9 Suppl 1):4-11.

  31. BIBBY BG. Fluoride mouthwashes, fluoride dentifrices, and other uses of fluorides in control of caries. J Dent Res. 1948;27(3):367-375. doi:10.1177/00220345480270031301.

  32. Stookey GK. Are all fluoride dentifrices the same? In: Wei SHY Clinical uses of fluoride. Lea & Febiger 1985, Philadelphia.

  33. Zacherl WA. A three-year clinical caries evaluation of the effect of a sodium fluoride-silica abrasive dentifrice. Pharmacol Ther Dent. 1981;6(1-2):1-7.

  34. Beiswanger BB, Gish CW, Mallatt ME. A three-year study of the effect of a sodium fluoride-silica abrasive dentifrice on dental caries. Pharmacol Ther Dent. 1981;6(1-2):9-16.

  35. Colgate Cavity Protection Information. Colgate-Cavity-Protection-Toothpaste/specifics. Accessed June 17, 2023.

  36. Shellis RP, Duckworth RM. Studies on the cariostatic mechanisms of fluoride. Int Dent J. 1994;44(3 Suppl 1):263-273.

  37. Zacherl WA. A three-year clinical caries evaluation of the effect of a sodium fluoride-silica abrasive dentifrice. Pharmacol Ther Dent. 1981;6(1-2):1-7.

  38. Hargreaves JA, Thompson GW, Wagg BJ. Changes in caries prevalence of Isle of Lewis children between 1971 and 1981. Caries Res. 1983;17(6):554-559. doi:10.1159/000260717.

  39. Stookey GK. Are all fluoride dentifrices the same? - Clinical Uses of Fluorides (Current Problems in Clinical Dentistry). Stephen H.Y. Wei (Ed). London. 1986. 105-131.

  40. Gerlach RW, Gibb RD, Sagel PA. A randomized clinical trial comparing a novel 5.3% hydrogen peroxide whitening strip to 10%, 15%, and 20% carbamide peroxide tray-based bleaching systems. Compend Contin Educ Dent Suppl. 2000 Jun;(29):S22-28.

  41. White DJ. A new and improved "dual action" whitening dentifrice technology--sodium hexametaphosphate. J Clin Dent. 2002;13(1):1-5.

  42. White DJ. A "return" to stannous fluoride dentifrices. J Clin Dent. 1995;6 Spec No:29-36.

  43. Tinanoff N. Progress regarding the use of stannous fluoride in clinical dentistry. J Clin Dent. 1995;6 Spec No:37-40.

  44. Robinson PJ. Gingivitis: a prelude to periodontitis? J Clin Dent. 1995;6 Spec No:41-45.

  45. Beiswanger BB, Doyle PM, Jackson RD, et al. The clinical effect of dentifrices containing stabilized stannous fluoride on plaque formation and gingivitis--a six-month study with ad libitum brushing. J Clin Dent. 1995;6 Spec No:46-53.

  46. Perlich MA, Bacca LA, Bollmer BW, et al. The clinical effect of a stabilized stannous fluoride dentifrice on plaque formation, gingivitis and gingival bleeding: a six-month study. J Clin Dent. 1995;6 Spec No:54-58.

  47. White DJ, Cox ER, Liang N, et al. A new Plaque Glycolysis and Regrowth Method (PGRM) for the in vivo determination of antimicrobial dentifrice/rinse efficacy towards the inhibition of plaque growth and metabolism--method development, validation and initial activity screens. J Clin Dent. 1995;6 Spec No:59-70.

  48. Kasturi R, White DJ, Lanzalaco AC, et al. Effects of nine weeks' use of a new stabilized stannous fluoride dentifrice on intrinsic plaque virulence expressed as acidogenicity and regrowth: a modified PGRM study. J Clin Dent. 1995;6 Spec No:71-79.

  49. Liang N, White DJ, Cox E, et al. Antimicrobial effects of a stabilized stannous fluoride dentifrice in reducing plaque acid production--a single-brushing PGRM study. J Clin Dent. 1995;6 Spec No:80-83.

  50. White DJ, Cox ER, Gwynn AV. Effect of a stabilized stannous fluoride dentifrice on plaque acid (toxin) production. J Clin Dent. 1995;6 Spec No:84-88.

  51. Faller RV, Best JM, Featherstone JD, Barrett-Vespone NA. Anticaries efficacy of an improved stannous fluoride toothpaste. J Clin Dent. 1995;6 Spec No:89-96.

  52. Weber DA, Howard-Nordan K, Buckner BA, et al. Microbiological assessment of an improved stannous fluoride dentifrice. J Clin Dent. 1995;6 Spec No:97-104.

  53. White DJ. Tartar control dentifrices: current status and future prospects - Clinical and biological aspects of dentifrices. Graham Embery (Ed). Oxford. Oxford University Press. 1992. 277-291.

  54. White DJ, McClanahan SF, Lanzalaco AC, et al. The comparative efficacy of two commercial tartar control dentifrices in preventing calculus development and facilitating easier dental cleanings. J Clin Dent. 1996;7(2 Spec No):58-64.

  55. Perlich MA, Berman E, Frataneangelo P, et al. Desensitizing efficacy of a 5% KNO3/0.243% NAF dentifrice. J Dent Res 1994; 73:166.

  56. Faller RV, Shaffer JB, Eversole S, et al. In vitro fluoride uptake from dentifrices containing sodium fluoride and potassium nitrate. J Dent Res 1994; 73:241.

  57. Lehne RK, Winston AE. Abrasivity of sodium bicarbonate. Clin Prev Dent. 1983 Jan-Feb;5(1):17-18.

  58. Ramji N, Baig A, He T, et al. Sustained antibacterial actions of a new stabilized stannous fluoride dentifrice containing sodium hexametaphosphate. Compend Contin Educ Dent. 2005;26(9 Suppl 1):19-28.

  59. Mankodi S, Bartizek RD, Winston JL, Biesbrock AR, McClanahan SF, He T. Anti-gingivitis efficacy of a stabilized 0.454% stannous fluoride/sodium hexametaphosphate dentifrice. J Clin Periodontol. 2005;32(1):75-80. doi:10.1111/j.1600-051X.2004.00639.x.

  60. He T, Huang S, Yue F, et al. A randomized, controlled comparison of a stannous-containing dentifrice for reducing gingival bleeding and balancing the oral microbiome relative to a positive control. American Journal of Dentistry. 2021 Aug;34(4):222-227. PMID: 34370916.

  61. Kruse AB, Schlueter N, Kortmann VK, Frese C, Anderson A, Wittmer A, Hellwig E, Vach K, Al-Ahmad A. Long-Term Use of Oral Hygiene Products Containing Stannous and Fluoride Ions: Effect on Viable Salivary Bacteria. Antibiotics. 2021; 10(5):481. https://doi.org/10.3390/antibiotics10050481

  62. Baig A, He T, Buisson J, Sagel L, Suszcynsky-Meister E, White DJ. Extrinsic whitening effects of sodium hexametaphosphate—a review including a dentifrice with stabilized stannous fluoride. Compend Contin Educ Dent. 2005;26(9 Suppl 1):47-53.

  63. Terézhalmy G, Chaves E, Bsoul S, Baker R, He T. Clinical evaluation of the stain removal efficacy of a novel stannous fluoride and sodium hexametaphosphate dentifrice. Am J Dent. 2007;20(1):53-58.

  64. Schiff T, He T, Sagel L, Baker R. Efficacy and safety of a novel stabilized stannous fluoride and sodium hexametaphosphate dentifrice for dentinal hypersensitivity. J Contemp Dent Pract. 2006;7(2):1-8. Published 2006 May 1.

  65. Johnson G, Brännström M. The sensitivity of dentin. Changes in relation to conditions at exposed tubule apertures. Acta Odontol Scand. 1974;32(1):29-38. doi:10.3109/00016357409002530.

  66. Favaro Zeola L, Soares PV, Cunha-Cruz J. Prevalence of dentin hypersensitivity: Systematic review and meta-analysis. J Dent. 2019 Feb;81:1-6. doi: 10.1016/j.jdent.2018.12.015. Epub 2019 Jan 11. PMID: 30639724.

  67. Soares ARDS, Chalub LLFH, Barbosa RS, Campos DEP, Moreira AN, Ferreira RC. Prevalence and severity of non-carious cervical lesions and dentin hypersensitivity: association with oral-health related quality of life among Brazilian adults. Heliyon. 2021 Mar 13;7(3):e06492. doi: 10.1016/j.heliyon.2021.e06492. PMID: 33748509; PMCID: PMC7970350.

  68. Brännström M, Johnson G, Nordenvall KJ. Transmission and control of dentinal pain: resin impregnation for the desensitization of dentin. J Am Dent Assoc. 1979;99(4):612-618. doi:10.14219/jada.archive.1979.0337.

  69. Petrou I, Heu R, Stranick M, et al. A breakthrough therapy for dentin hypersensitivity: how dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth. J Clin Dent. 2009;20(1):23-31.

  70. Litkowski L, Greenspan DC. A clinical study of the effect of calcium sodium phosphosilicate on dentin hypersensitivity--proof of principle. J Clin Dent. 2010;21(3):77-81.

  71. Gendreau L, Barlow AP, Mason SC. Overview of the clinical evidence for the use of NovaMin in providing relief from the pain of dentin hypersensitivity. J Clin Dent. 2011;22(3):90-95.

  72. Melo Alencar, et al. Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysis, Journal of Dentistry, Volume 82, 2019, Pages 11-21, ISSN 0300-5712, https://doi.org/10.1016/j.jdent.2018.12.014.

  73. White DJ, Lawless MA, Fatade A, et al. Stannous fluoride/sodium hexametaphosphate dentifrice increases dentin resistance to tubule exposure in vitro. J Clin Dent. 2007;18(2):55-59.

  74. Stookey GK, Mau MS, Isaacs RL, Gonzalez-Gierbolini C, Bartizek RD, Biesbrock AR. The relative anticaries effectiveness of three fluoride-containing dentifrices in Puerto Rico. Caries Res. 2004;38(6):542-550. doi:10.1159/000080584.

  75. Mallatt M, Mankodi S, Bauroth K, Bsoul SA, Bartizek RD, He T. A controlled 6-month clinical trial to study the effects of a stannous fluoride dentifrice on gingivitis. J Clin Periodontol. 2007;34(9):762-767. doi:10.1111/j.1600-051X.2007.01109.x.

  76. Schiff T, Saletta L, Baker RA, Winston JL, He T. Desensitizing effect of a stabilized stannous fluoride/Sodium hexametaphosphate dentifrice. Compend Contin Educ Dent. 2005;26(9 Suppl 1):35-40.

  77. Hooper SM, Newcombe RG, Faller R, Eversole S, Addy M, West NX. The protective effects of toothpaste against erosion by orange juice: studies in situ and in vitro. J Dent. 2007;35(6):476-481. doi:10.1016/j.jdent.2007.01.003.

  78. Huysmans MC, Jager DH, Ruben JL, Unk DE, Klijn CP, Vieira AM. Reduction of erosive wear in situ by stannous fluoride-containing toothpaste. Caries Res. 2011;45(6):518-523. doi:10.1159/000331391.

  79. Bellamy PG, Harris R, Date RF, et al. In situ clinical evaluation of a stabilised, stannous fluoride dentifrice [published correction appears in Int Dent J. 2014 Jun;64(3):171. Manly, Andrew [corrected to Manley, Andrew]]. Int Dent J. 2014;64 Suppl 1:43-50. doi:10.1111

  80. Faller RV, Eversole SL. Enamel protection from acid challenge--benefits of marketed fluoride dentifrices. J Clin Dent. 2013;24(1):25-30.

  81. Eversole SL, Saunders-Burkhardt K, Faller RV. Erosion protection comparison of stabilised SnF2 , mixed fluoride active and SMFP/arginine-containing dentifrices. Int Dent J. 2014;64 Suppl 1:22-28. doi:10.1111/idj.12099.

  82. Eversole SL, Saunders-Burkhardt K, Faller RV. Erosion Prevention Potential of an Over-the-Counter Stabilized SnF2 Dentifrice Compared to 5000 ppm F Prescription-Strength Products. J Clin Dent. 2015;26(2):44-49.

  83. Faller RV, Eversole SL, Tzeghai GE. Enamel protection: a comparison of marketed dentifrice performance against dental erosion. Am J Dent. 2011;24(4):205-210.

  84. Baig AA, Faller RV, Yan J, Ji N, Lawless M, Eversole SL. Protective effects of SnF2 - Part I. Mineral solubilisation studies on powdered apatite. Int Dent J. 2014;64 Suppl 1:4-10. doi:10.1111/idj.12096.

  85. Khambe D, Eversole SL, Mills T, Faller RV. Protective effects of SnF2 - Part II. Deposition and retention on pellicle-coated enamel. Int Dent J. 2014;64 Suppl 1:11-15. doi:10.1111/idj.12097.

  86. Lussi A, Carvalho TS. The future of fluorides and other protective agents in erosion prevention. Caries Res. 2015;49 Suppl 1:18-29. doi:10.1159/000380886.

  87. Lussi A. Erosive tooth wear – a multifactorial condition of growing concern and increasing knowledge - Dental Erosion: From Diagnosis to Therapy. Lussi A (Ed). Basel, NY. Karger. 2006. 1-8.

  88. Dugmore CR, Rock WP. A multifactorial analysis of factors associated with dental erosion. Br Dent J. 2004 Mar 13;196(5):283-286. doi:10.1038/sj.bdj.4811041.

  89. Lussi A, Jaeggi T, Zero D. The role of diet in the aetiology of dental erosion. Caries Res. 2004;38 Suppl 1:34-44. doi:10.1159/000074360.

  90. Gambon DL, Brand HS, Veerman EC. Dental erosion in the 21st century: what is happening to nutritional habits and lifestyle in our society? Br Dent J. 2012 Jul 27;213(2):55-57. doi:10.1038/sj.bdj.2012.613.

  91. Cheaib Z, Lussi A. Impact of acquired enamel pellicle modification on initial dental erosion. Caries Res. 2011;45(2):107-112. doi:10.1159/000324803.

  92. Vieira A, Overweg E, Ruben JL, Huysmans MC. Toothbrush abrasion, simulated tongue friction and attrition of eroded bovine enamel in vitro. J Dent. 2006 May;34(5):336-342. doi:10.1016/j.jdent.2005.07.010.

  93. von Fraunhofer JA, Rogers MM. Dissolution of dental enamel in soft drinks. Gen Dent. 2004 Jul-Aug;52(4):308-12.

  94. Hooper SM, Newcombe RG, Faller R et al. The protective effects of toothpaste against erosion by orange juice: studies in situ and in vitro. J Dent. 2007 Jun;35(6):476-481. doi:10.1016/j.jdent.2007.01.003.

  95. Baig AA, Faller RV, Yan J, et al. Protective effects of SnF2 - Part I. Mineral solubilisation studies on powdered apatite. Int Dent J. 2014 Mar;64 Suppl 1:4-10. doi:10.1111/idj.12096.

  96. Khambe D, Eversole SL, Mills T et al. Protective effects of SnF2 - Part II. Deposition and retention on pellicle-coated enamel. Int Dent J. 2014 Mar;64 Suppl 1:11-15. doi:10.1111/idj.12097.

  97. Faller RV, Eversole SL. Protective effects of SnF2 - Part III. Mechanism of barrier layer attachment. Int Dent J. 2014 Mar;64 Suppl 1:16-21. doi:10.1111/idj.12098

  98. Eversole SL, Saunders-Burkhardt K, Faller RV. Erosion protection comparison of stabilised SnF2 , mixed fluoride active and SMFP/arginine-containing dentifrices. Int Dent J. 2014 Mar;64 Suppl 1:22-28. doi:10.1111/idj.12099.

  99. Faller RV, Eversole SL, Saunders-Burkhardt K. Protective benefits of a stabilised stannous-containing fluoride dentifrice against erosive acid damage. Int Dent J. 2014 Mar;64 Suppl 1:29-34. doi:10.1111/idj.12100.

  100. Hooper S, Seong J, Macdonald E, et al. A randomised in situ trial, measuring the anti-erosive properties of a stannous-containing sodium fluoride dentifrice compared with a sodium fluoride/potassium nitrate dentifrice. Int Dent J. 2014 Mar;64 Suppl 1:35-42. doi:10.1111/idj.12101.

  101. Bellamy PG, Harris R, Date RF, et al. In situ clinical evaluation of a stabilised, stannous fluoride dentifrice. Int Dent J. 2014 Mar;64 Suppl 1:43-50. doi:10.1111/idj.12102.

  102. Eversole SL, Saunders-Burkhardt K, Faller RV. Erosion prevention potential of an over-the-counter stabilized SnF2 dentifrice compared to 5000 ppm F prescription-strength products. J Clin Dent 2015;26:44-49.

  103. West NX, He T, Hellin N, et al. Randomized in situ clinical trial evaluating erosion protection efficacy of a 0.454% stannous fluoride dentifrice. Int J Dent Hyg. 2019;17(3):261-267. doi:10.1111/idh.12379.

  104. West NX, Hellin N, Eusebio R, He T. The erosion protection efficacy of a stabilized stannous fluoride dentifrice: An in situ randomized clinical trial. Am J Dent. 2019;32(3):138-142.

  105. West N, He T, Hellin N, et al. Erosion protection efficacy of a 0.454% stannous fluoride dentifrice versus an arginine-containing dentifrice. Am J Dent. 2018;31(2):63-66.

  106. Zhao X, He T, He Y, Cheng C, Chen H. A Randomized Clinical Trial to Measure the Erosion Protection Benefits of a Novel Stabilized Stannous Fluoride Dentifrice versus a Control Dentifrice. J Clin Dent. 2017;28(4 Spec No B):B17-B20.

  107. American Dental Association. Joint Report of the American Dental Association Council on Access, Prevention and Interprofessional Relations and Council on Scientific Affairs to the House of Delegates: Response to Resolution 73H-2000. 2001 Oct. Accessed June 17, 2023.

  108. Imfeld T. Dental erosion. Definition, classification and links. Eur J Oral Sci. 1996;104(2 ( Pt 2)):151-155. doi:10.1111/j.1600-0722.1996.tb00063.x.

  109. ten Cate JM, Imfeld T. Dental erosion, summary. Eur J Oral Sci. 1996;104(2 ( Pt 2)):241-244. doi:10.1111/j.1600-0722.1996.tb00073.x.

  110. Johansson AK, Lingström P, Imfeld T, Birkhed D. Influence of drinking method on tooth-surface pH in relation to dental erosion. Eur J Oral Sci. 2004;112(6):484-489. doi:10.1111/j.1600-0722.2004.00172.x.

  111. Jin Y, Yip HK. Supragingival calculus: formation and control. Crit Rev Oral Biol Med. 2002;13(5):426-441. doi:10.1177/154411130201300506.

  112. Bollmer BW, Sturzenberger OP, Vick V, Grossman E. Reduction of calculus and Peridex stain with Tartar-Control Crest. J Clin Dent. 1995;6(4):185-187.

  113. Pradeep AR, Agarwal E, P AR, Rao MS, Faizuddin M. Study of orthophosphate, pyrophosphate, and pyrophosphatase in saliva with reference to calculus formation and inhibition. J Periodontol. 2011;82(3):445-451. doi:10.1902/jop.2010.100355.

  114. White DJ. A new and improved "dual action" whitening dentifrice technology—sodium hexametaphosphate. J Clin Dent. 2002;13(1):1-5.

  115. White D, Cox E, Suszcynskymeister E, Baig AA. In vitro studies of the anticalculus efficacy of a sodium hexametaphosphate whitening dentifrice. J Clin Dent. 2002;13(1):33-37.

  116. Segreto VA, Collins EM, D'Agostino R, Cancro LP, Pfeifer HJ, Gilbert RJ. Anticalculus effect of a dentifrice containing 0.5% zinc citrate trihydrate. Community Dent Oral Epidemiol. 1991;19(1):29-31. doi:10.1111/j.1600-0528.1991.tb00100.x.

  117. Schemehorn BR, Moore MH, Putt MS. Abrasion, polishing, and stain removal characteristics of various commercial dentifrices in vitro. J Clin Dent. 2011;22(1):11-18.

  118. Hattab FN, Qudeimat MA, al-Rimawi HS. Dental discoloration: an overview. J Esthet Dent. 1999;11(6):291-310. doi:10.1111/j.1708-8240.1999.tb00413.x.

  119. Hefferren JJ. A laboratory method for assessment of dentifrice abrasivity. J Dent Res. 1976;55(4):563-573. doi:10.1177/00220345760550040301.

  120. St John S, White DJ. History of the Development of Abrasivity Limits for Dentifrices. J Clin Dent. 2015;26(2):50-54.

  121. He T, Baker R, Bartizek RD, Biesbrock AR, Chaves E, Terézhalmy G. Extrinsic stain removal efficacy of a stannous fluoride dentifrice with sodium hexametaphosphate. J Clin Dent. 2007;18(1):7-11.

  122. Feng X, Chen X, Cheng R, Sun L, Zhang Y, He T. Breath malodor reduction with use of a stannous-containing sodium fluoride dentifrice: a meta-analysis of four randomized and controlled clinical trials. Am J Dent. 2010;23 Spec No B:27B-31B.

  123. Silva MF, Leite FRM, Ferreira LB, Pola NM, Scannapieco FA, Demarco FF, Nascimento GG. Estimated prevalence of halitosis: a systematic review and meta-regression analysis. Clin Oral Investig. 2018 Jan;22(1):47-55. doi: 10.1007/s00784-017-2164-5. Epub 2017 Jul 4. PMID: 28676903.

  124. Liu XN, Shinada K, Chen XC, Zhang BX, Yaegaki K, Kawaguchi Y. Oral malodor-related parameters in the Chinese general population. J Clin Periodontol. 2006;33(1):31-36. doi:10.1111/j.1600-051X.2005.00862.x.

  125. Miyazaki H, Sakao S, Katoh Y, Takehara T. Correlation between volatile sulphur compounds and certain oral health measurements in the general population. J Periodontol. 1995;66(8):679-684. doi:10.1902/jop.1995.66.8.679.

  126. Silva MF, Leite FRM, Ferreira LB, Pola NM, Scannapieco FA, Demarco FF, Nascimento GG. Estimated prevalence of halitosis: a systematic review and meta-regression analysis. Clin Oral Investig. 2018 Jan;22(1):47-55. doi: 10.1007/s00784-017-2164-5. Epub 2017 Jul 4. PMID: 28676903.

  127. Iwanicka-Grzegorek E, Michalik J, Kepa J, Wierzbicka M, Aleksinski M, Pierzynowska E. Subjective patients' opinion and evaluation of halitosis using halimeter and organoleptic scores. Oral Dis. 2005;11 Suppl 1:86-88. doi:10.1111/j.1601-0825.2005.01101.x.

  128. Bornstein MM, Kislig K, Hoti BB, Seemann R, Lussi A. Prevalence of halitosis in the population of the city of Bern, Switzerland: a study comparing self-reported and clinical data. Eur J Oral Sci. 2009;117(3):261-267. doi:10.1111/j.1600-0722.2009.00630.x.

  129. Preti G, Clark L, Cowart BJ, et al. Non-oral etiologies of oral malodor and altered chemosensation. J Periodontol. 1992;63(9):790-796. doi:10.1902/jop.1992.63.9.790.

  130. ADA Council on Scientific Affairs. Oral malodor. J Am Dent Assoc. 2003;134(2):209-214. doi:10.14219/jada.archive.2003.0135.

  131. Kleinberg I, Westbay G. Salivary and metabolic factors involved in oral malodor formation. J Periodontol. 1992 Sep;63(9):768-775. doi: 10.1902/jop.1992.63.9.768.

  132. Rosenberg M. The science of bad breath. Sci Am. 2002;286(4):72-79. doi:10.1038/scientificamerican0402-72.

  133. Rosenberg M. Bad breath: Research perspectives. Ramat Aviv: Ramot Publishing-Tel Aviv University 1997.

  134. Haraszthy VI, Zambon JJ, Sreenivasan PK, et al. Identification of oral bacterial species associated with halitosis. J Am Dent Assoc. 2007;138(8):1113-1120. doi:10.14219/jada.archive.2007.0325.

  135. De Boever EH, Loesche WJ. Assessing the contribution of anaerobic microflora of the tongue to oral malodor. J Am Dent Assoc. 1995;126(10):1384-1393. doi:10.14219/jada.archive.1995.0049.\

  136. Rosenberg M. Clinical assessment of bad breath: current concepts [published correction appears in J Am Dent Assoc 1996 May;127(5):570]. J Am Dent Assoc. 1996;127(4):475-482. doi:10.14219/jada.archive.1996.0239.

  137. Lee CH, Kho HS, Chung SC, Lee SW, Kim YK. The relationship between volatile sulfur compounds and major halitosis-inducing factors. J Periodontol. 2003;74(1):32-37. doi:10.1902/jop.2003.74.1.32.

  138. Yaegaki K, Sanada K. Volatile sulfur compounds in mouth air from clinically healthy subjects and patients with periodontal disease. J Periodontal Res. 1992;27(4 Pt 1):233-238. doi:10.1111/j.1600-0765.1992.tb01673.x.

  139. Ratcliff PA, Johnson PW. The relationship between oral malodor, gingivitis, and periodontitis. A review. J Periodontol. 1999;70(5):485-489. doi:10.1902/jop.1999.70.5.485.

  140. Bakdash B. Current patterns of oral hygiene product use and practices. Periodontol 2000. 1995;8:11-14. doi:10.1111/j.1600-0757.1995.tb00041.x.

  141. van der Weijden GA, Hioe KP. A systematic review of the effectiveness of self-performed mechanical plaque removal in adults with gingivitis using a manual toothbrush. J Clin Periodontol. 2005;32 Suppl 6:214-228. doi:10.1111/j.1600-051X.2005.00795.x.

  142. Donovan-Brand R. A comparison of the breath and antimicrobial efficacies of various antimicrobial systems present in commercial dental products. J Dent Res 2003; 82 (Sp Iss):501.

  143. Navada R, Kumari H, Le S, Zhang J. Oral malodor reduction from a zinc-containing toothpaste. J Clin Dent. 2008;19(2):69-73.

  144. Chen X, He T, Sun L, Zhang Y, Feng X. A randomized cross-over clinical trial to evaluate the effect of a 0.454% stannous fluoride dentifrice on the reduction of oral malodor. Am J Dent. 2010;23(3):175-178.

  145. Mäkinen KK. Sugar alcohol sweeteners as alternatives to sugar with special consideration of xylitol. Med Princ Pract. 2011;20(4):303-320. doi:10.1159/000324534.

  146. Biesbrock, A et al. The Effects of Bioavailable Gluconate Chelated Stannous. Fluoride Dentifrice on Gingival Bleeding: Meta-Analysis of Eighteen Randomized Controlled Trials. J Clin Periodontal, 2019.

  147. West N. et al. Bioavailable gluconate chelated stannous fluoride toothpaste meta-analyses: Effects on dentine hypersensitivity and enamel erosion. Journal of Dentistry, Volume 105, 2021

  148. Zsiska M, Schneiderman E, Jin Y, Farrell S, Grender J. Investigation of oral malodor prevention by dentifrices as measured by VSC reduction. J Breath Res. 2021 Apr 13;15(3). doi: 10.1088/1752-7163/abf209. PMID: 33765667.